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VB and PV: Critically reviewed the manuscript and provided intellectual inputs

Although there was no expectation that acute loss of function would match that from chronic reduction, we still observed several splicing alterations in the mutant fibroblasts that showed the same trends as the changes produced by FUS/TLS or SMN knockdown

patients should follow the advice of their own bariatric team.) Because intrinsic factor production is reduced after surgery, the standard oral route of B12 absorption which relies on intrinsic factor is less reliable

Abbreviations CVD cardiovascular disease CRP C reactive protein DBP diastolic blood pressure FPG fasting plasma glucose IL interleukin GRADE Grading of Recommendations Assessment Development and Evaluation HbA1c glycated hemoglobin HDL high-density lipoprotein LDL low-density lipoprotein MDA malondialdehyde PRISMA Preferred Reporting Items for Systematic reviews and Meta-Analysis RCT randomized controlled trials SBP systolic blood pressure SMD standard mean difference T2D type 2 diabetes