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06 Progressive abdominal distension If waist circumference rises despite stable body composition and training, discontinue the cycle

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Currently, the widely accepted pathogenic hypotheses include the Monoamine hypothesis, the Neural plasticity hypothesis, the Neuroinflammatory hypothesis, and the Hypothalamic-pituitary-adrenal (HPA) axis (Figure 1) (Subermaniam et al., 2021a

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Pertinent to hypoxic NO generation from nitrite, this N 2 O 3 liberation by Hb represents ferrihaemnitrite disproportionation or a nitrite anhydrase mechanism