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The recent meta-analyses indicated that in patients with high TMAO plasma level, the incidence of major adverse cardiovascular events was significantly higher compared with patients with low TMAO levels [67], and that all-cause mortality increased by 7.6% per each 10 mol/L increment of TMAO [68]

Exercise intolerance is evident in DOCA-salt mice after TAC ( 2.1.4 Dahl salt-sensitive rats (H 2 FPEF score 4) This strain of salt-sensitive Sprague-Dawley rats is only genetically distinguishable from the salt-resistant Dahl rat strain by a polymorphism in the renin gene ( 2.1.5 Spontaneous hypertensive rats (H 2 FPEF score 4) Originally used to model essential hypertension in human, this inbred strain of rats develops concentric LV hypertrophy with preserved systolic function ( 2.2 Aging According to the Framingham Heart Study and Baltimore Longitudinal Study on Aging, aging positively correlates with prevalence of LV hypertrophy, even in the absence of hypertension

10.1111/jpi.12310 J

doi: 10.1016/j.jamda.2012.05.020

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