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Effectivecombinationtherapiesareurgentlyneededtotreattriple-negativebreastcancer(TNBC),whichisinsensitivetotheexistingtreatmentregimens.However,thesynergisticpotencyoftraditionalsmall-moleculecombinationsislimitedmainlyduetomismatchedmolarratios,inconsistentpharmacokinetics,andintratumoralaccumulationofindividualdrugs.Currentnanotechnologyoffersanunparalleleddevelopmentonadvancedcombinationdrugdelivery,especiallyratiometricdrugdeliveryinvivo.Recently,Prof.LIUXiangruiandProf.ZHOUTianhuafromtheZhe