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The link to autoimmune disease is leaky gut and many patients with MTHFR polymorphisms have imbalanced microbes in the gut which lead to dysbiosis and autoimmune disease -you can read more about that link here My husband and I are both negative for C677T, but both hetero for A1298C

Koepsell H (2013) The SLC22 family with transporters of organic cations, anions and zwitterions

Acta Biomater 159 , 300311 (2023)

nucleatum fusiforme , Treponema denticola , Bacteroides Loescheii , Porphyromonas gingivalis , Bacteroides inermedius and Peptostreptococcus micros , are capable of metabolizing L-cysteine or degrading glutathione to form hydrogen sulfide (H 2 S) within the periodontal pocket, which is toxic to mammalian cells by inactivating cytochrome oxidase, and is also reported to inhibit the catalase.[5,34] Mkinen and Mkinen[131] reported the presence of enzyme GGT (that breaks down glutathione to Cys-Gly in human cell membrane) in the outer cell envelope of T

10.1093/intimm/dxu056 Int Immunol

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