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Here are key red flags to act on right away: In emergencies like DVT or arterial blockages, waiting too long can lead to life-threatening complications such as stroke, pulmonary embolism, or tissue death (gangrene)

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Symptoms: persistent redness, new breakouts, increased sensitivity, skin that worsens rather than improves over time

This raises the interesting question of whether vaccination prior to the first influenza infection can be tailored to shape a more broadly protective immune response throughout life [125]