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In humans contradictory observations still exist, since some lines of evidence suggest that supplementation of the diet with fish oils results in a reduced production of IL-1, IL-6, TNF-, and IL-2 [190], and an alteration of gene expression profiles to a more antiinflammatory and antiatherogenic status in peripheral blood mononuclear cells in vitro [191]

In 2023, a clinical trial (N = 90 LOE 3a) with daily supplementation of 3 g LC in the experimental group and equivalent placebo in the control group was conducted

Helps reduce body fat and manage weight

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The best sources include: Red meat (especially lamb and beef) Fish Poultry Dairy products Smaller amounts are found in some plant sources like avocado and asparagus, but generally, vegetarian and vegan diets provide less L-carnitine