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The agitation creates shear forces that damage the delicate molecular structure

Abbreviations 5HT 5hydroxytryptamine, serotonin 7nAChR 7 nicotinic acetylcholine receptor ABVN auricular branch of the vagus nerve ACC anterior cingulate cortex ACh acetylcholine ACTH adrenocorticotropic hormone AD Alzheimer's disease ADAScog Alzheimer's Disease Assessment ScaleCognitive Subscale (ADASCog) ADHD attentiondeficit/hyperactivity disorder AF atrial fibrillation AI artificial intelligence AKI acute kidney injury AMPK AMPactivated protein kinase ARDS acute respiratory distress syndrome ASD autism spectrum disorder AV atrioventricular BAT Brown adipose tissue BBB bloodbrain barrier BDNF brainderived neurotrophic factor CAP cholinergic antiinflammatory pathway CCK cholecystokinin CKD chronic kidney disease CNS central nervous system CRH corticotropinreleasing hormone CRP Creactive protein CRSR Revised Coma Recovery Scale DA dopamine DAS descending antinociceptive systems DH dorsal horn DMV dorsal motor nucleus of the vagus DNIC diffuse noxious inhibitory control DoC disorders of consciousness DRN dorsal raphe nucleus EEG electroencephalogram EGC enteric glial cells FDA Food and Drug Administration fMRI functional magnetic resonance imaging FUS focused ultrasound stimulation GABA aminobutyric acid GAD generalized anxiety disorder GI gastrointestinal HFpEF heart failure with preserved ejection fraction HFrEF heart failure with reduced ejection fraction HPA hypothalamicpituitaryadrenal HR heart rate HRV heart rate variability I/R ischemiareperfusion IBD inflammatory bowel disease IBS irritable bowel syndrome IL10 interleukin10 IL1 interleukin1 beta IL4 interleukin4 IL6 interleukin6 IL8 interleukin8 iVNS invasive vagus nerve stimulation LC locus coeruleus LTD longterm depression LTP longterm potentiation LVEF left ventricular ejection fraction MADRS Montgomerysberg Depression Rating Scale MI myocardial infarction MMSE MiniMental State Examination mPFC medial PFC mVNS magnetic vagus nerve stimulation NE norepinephrine NO nitric oxide NOS nitric oxide synthase NTS nucleus tractus solitarius NYHA New York Heart Association OCD obsessivecompulsive disorder oVNS optogenetic vagus nerve stimulation PAG periaqueductal gray paVNS percutaneous auricular vagus nerve stimulation PBN parabrachial nucleus PD Parkinson's disease PET positron emission tomography PFC prefrontal cortex pSS primary Sjgren's syndrome PTSD posttraumatic stress disorder PVN paraventricular nucleus RA rheumatoid arthritis RAAS reninangiotensinaldosterone system RCT randomized controlled trial ROS reactive oxygen species RSA respiratory sinus arrhythmia RVM rostral ventromedial medulla SA sinoatrial SLE systemic lupus erythematosus SSc systemic sclerosis taVNS transcutaneous auricular vagus nerve stimulation TBI traumatic brain injury tcVNS transcutaneous cervical vagus nerve stimulation TNF tumor necrosis factor alpha vBloc vagal blocking VIP vasoactive intestinal polypeptide vmPFC ventromedial prefrontal cortex VN vagus nerve VNS vagus nerve stimulation VTA ventral tegmental area 1

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"AngIV-analog dihexa rescues cognitive impairment and recovers memory in the APP/PS1 mouse via the PI3K/AKT signaling pathway."Brain sciences11.11 (2021): 1487