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Severe BIPN can result in muscle atrophy, diminished ankle reflexes, and reduced proprioception, leading to foot drop, ataxia, and gait disturbances, all of which can impair daily functioning (Yamamoto and Egashira, 2021

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Notably, these phenotypic featuressuch as metabolic shifts in breast cancer modelsinteract dynamically with the immune microenvironment, enabling ferroptosis to serve as a lever for reversing resistance via pathways like IFN- signaling.Recent studies have revealed that most drug-resistant cancer cellsparticularly subtypes with a mesenchymal phenotype and high metastatic potentialexhibit a uniquely heightened sensitivity to ferroptosis ( 2.1 Metabolic reprogramming features Metabolic reprogramming enables tumor cells to adapt to proliferative demands and hostile microenvironments by remodeling key metabolic pathways