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PMC 8793015

9,10,11 Current research on the treatment of TRD focuses on personalized approaches and novel pharmacological interventions over standard medications

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The mechanism involves: Cholinergic antagonism -- cortistatin reduces cortical arousal by antagonizing acetylcholine-mediated excitation, effectively dampening the wake-promoting cholinergic system that maintains cortical desynchronization during wakefulness EEG synchronization -- the transition from wakefulness to SWS is characterized by increasingly synchronized, high-amplitude delta waves on EEG