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Furthermore, the preference of glycolysis over OXPHOS results in a reduction of ROS generation, which in combination with increased stress defense mechanisms, results in extended cell survival with maximal safeguard from genome instability ( 4 Mitochondrial physiology during reprogramming and differentiation Cellular reprogramming requires extensive mitochondrion architectural reorganization and metabolic shift to balance the need for pluripotency and self-renewal

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[DOI] [PubMed] [Google Scholar] 369.Damera G., Fogle H., Lim P., Goncharova E., Zhao H., Banerjee A., Tliba O., Krymskaya V., Panettieri R., Jr

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