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In fact, buccal permeability of macromolecules is generally limited to peptides under 2040 kDa, with sublingual mucosa sometimes permitting compounds up to 70 kDa with the use of penetration enhancers

& GREEN, J.A

Notably, FOXO4-DRI treatment did not cause significant changes in body weight or testis weight, suggesting a targeted effect [1]

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PMCID: PMC10680828

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