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Neutralizing ADAs (NAbs) directly inhibit the biological activity of the protein therapeutic by binding to its active site or to regions critical for its function [11], thereby reducing the efficacy of the therapy

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Because these peptides do not alter endocrine or hormonal pathways, background variable noise remains extremely low.

Sen S, Mondal S, Zheng L, Salinger AJ, Fast W, Weerapana E, Thompson PR (2019) Development of a suicide inhibition-based protein labeling strategy for nicotinamide N -methyltransferase

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