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[24] The beta-catenin pathway, a key component of the Wnt signaling pathway, translocates into the nucleus following MET activation and participates in transcriptional regulation of numerous genes

R., Converging Pathways in Neurodegeneration, From Genetics to Mechanisms, Nature Neuroscience 21, no

Spi 8, 450457

For example, induction of ferroptosis via GPX4 inhibition often triggers upregulation of ferroptosis suppressor protein 1 (FSP1)-mediated lipid peroxide detoxification, reducing long-term therapeutic efficacy (175, 176)

In a KRAS G12D mutant lung cancer and CT26 colon cancer mouse models, the depletion of fibroblast activation protein (FAP), expressed by CAFs, was demonstrated to inhibit tumor cell proliferation through accumulation of collagen and decrease of myofibroblast content and blood vessel density (131)