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Synaptic dysfunction and loss, particularly in the hippocampus and cerebral cortex, are early events in AD and correlate strongly with cognitive decline (Selkoe 2002
10.1038/ncomms12015 211 JarrettJ

While nitric oxide can be formed directly from L-arginine, L-citrulline is converted first and thus acts with a delay
Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition

There are other live style changes and strategies that individuals can utilize in order fend off feelings of depression

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