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However, shifting the schedule can still cause a temporary flare of these symptoms

126 Adipocyte size and triglyceride content were also reduced and hepatic steatosis was prevented

doi: 10.1016/j.npep.2018.07.003 76 BrauerRWeiLMaTAthaudaDGirgesCVijiaratnamNet al

In Phase 2 clinical trials published in the New England Journal of Medicine, retatrutide produced average weight reductions of 24.2% of body weight at 48 weeks at the highest dose the highest weight loss efficacy ever documented for a pharmacological agent in a clinical trial at the time of publication

Consider staying at a lower dose long-term if it provides good weight loss with manageable side effects

Should older adults be concerned about muscle loss with GLP-1 medications