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It can participate in one-carbon metabolism through serine hydroxymethyltransferase (SHMT) to support nucleotide synthesis, and can also serve as a component of glutathione (GSH) in maintaining cellular redox homeostasis ( Threonine (Thr) can likewise enter the one-carbon metabolic network and can be converted by threonine dehydrogenase (TDH) into intermediates such as acetyl-CoA, thereby providing a link between energy metabolism and epigenetic regulation ( Overall, the effects of Ser/Gly/Thr metabolism on macrophage polarization are mainly mediated by changes in one-carbon metabolic flux, methyl donor availability, and redox homeostasis, and the resulting outcome is often manifested as threshold regulation of inflammatory transcriptional programs and alterations in phenotypic stability

Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al

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Bai S, Lu Z, Jiang Y, Shi X, Xu D, Shi Y, et al