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Expression of endothelin-3 (ET-3) is mainly localized to neurons and glia of the neostriatum, hypothalamic nuclei, hippocampus, and Purkinje cells of the cerebellum and medulla oblongata
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Moreover, vitamin C administration reduced collagen deposition in the bronchioles as well as the presence of cytochrome c, Bcl-2-associated X protein (Bax)/B-cell leukemia/lymphoma 2 (BCL-2) ratio, p53, caspase 3, caspase 8 and poly-ADP-ribose polymerase (PARP) activity and deoxyribonucleic acid (DNA) fragmentation in the lungs, indicating decreased airway remodeling and apoptosis (Ghosh et al
