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Besides inhibiting the Xc- antiporter, erastin is also an activator of the mitochondrial voltage-dependent-anion channel (VDAC) by reversing the inhibitory effect of tubulin on VDAC, thus increasing oxidative phosphorylation, ATP, ROS production and mitochondrial membrane permeabilization

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Nanoparticle-mediated delivery of siRNA for effective lung cancer therapy

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doi: 10.1089/thy.2013.0058 78