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FIGURE 2 3.2 Inflammatory pathway activation via mtROS and mtDNA leakage 3.2.1 mtROS and the NLRP3 inflammasome mtROS is a potent activator of the NLRP3 inflammasome, a multiprotein platform composed of NLRP3, ASC, and caspase-1 (Jang et al., 2015
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Either way, the message gets delivered just with some difference in timing
Huang X, Bedoyan JK, Demirbas D, Harris DJ, Miron A, Edelheit S, et al
Plebanek, M
For instance, the free intracellular Cu during the transition between the Cu + and Cu 2+ states can produce hydroxyl radicals, namely, reactive oxygen species (ROS) [8]
