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Then, the mixture was incubated for 1 h before centrifugation at 15000 g for 15 min at 4 C

What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions

Science 322, 587590

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Beyond its role in lung tissues, MTH1 plays a crucial part in vascular health, particularly in pulmonary arterial hypertension (PAH), a severe condition marked by abnormally high pulmonary artery pressure and right ventricular failure