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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Pela R, Calcagni AM, Subiaco S, Isidori P, Tubaldi A, Sanguinetti CM

Despite a dearth of comprehensive evidence for numerous pharmacological interventions, healthcare providers have turned to symptomatic treatments to mitigate a spectrum of issues, including psychological distress like anxiety and depression, emotional volatility (pseudobulbar affect), involuntary muscle twitches, pervasive fatigue, sleep disturbances, and a range of physical discomforts from muscle cramps and spasms to immobility-induced musculoskeletal pain, neuropathic pain, sialorrhea, spasticity, constipation, and urinary urgencies

Br J Clin Pharmaol 22: 649657, 1986 [DOI] [PMC free article] [PubMed] [Google Scholar] 62.Kane RE, Tector J, Brems JJ, Li A, Kaminski D: Sulfation and glucuronidation of acetaminophen by cultured hepatocytes reproducing in vivo sex-differences in conjugation on Matrigel and type 1 collagen

127, July 2024, pp

Future research is needed to fully elucidate these mechanisms and optimize treatment protocols (Fattorusso et al., 2019