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First-line medications with the strongest evidence: duloxetine (60120mg daily FDA-approved for diabetic peripheral neuropathic pain

Spray Application Spraying provides: A consistent, uniform film Excellent coverage across pavement aggregate Greater control on large projects For best results, each spray should overlap 50% into the previous pass to prevent streaking and ensure even coverage

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Yellow, brown, or any color change signals degradation

In addition, women must continue to consume adequate amounts of B12 while breastfeeding