glutathione a powerful endogenous antioxidant system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis The Role of Glutathione Metabolism

Then, the inserts containing cells were placed into 24-well plates containing endothelial culture medium

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Immunofluorescence staining analysis showed that at day 20 all of the cells in four groups expressed albumin (ALB) and glutathione S-transferase alpha 2 (GSTA2), which were similar with human hepatocytes (Fig

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Decreased expression of GPx1 by iberin results in an accumulation of detrimental concentrations of ROS (measured by DCF fluorescence) that inhibits cell proliferation, induces cell cycle arrest, and promotes apoptosis, whereas the forced upregulation of GPx1 or antioxidant treatment attenuates these therapeutic actions [143]