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However, analysis of pH dependent labeling by 4-(ethylthio)-1,3-cyclopentanedione showed that probe labeling increased at lower pH, in contrast to data obtained for DCP-Bio1

However, in other cases, some glutathione S -conjugates may enter the circulation from the brush-border membranes of the gut cells via a mechanism that does not require GGT

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This phenomenon was first described by Lemasters group [37] when APAP-induced MPTP opening and necrotic cell death in primary isolated hepatocytes was attenuated by MPTP inhibitors at early time points but not late time points where caspase activation was detected