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Despite compelling preclinical evidence for fibrosis resolution and anti-inflammatory effects, formidable translational barriersincluding the limited persistence (107), and host immune clearance (108) of adoptively transferred macrophagesmust be overcome before the clinical potential of CAR-M can be realistically assessed

Stasis of the submucosal blood vessels was also present but to a much lesser extent than in controls

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The constrictor response to urotensin-II appears to be variable and highly dependent on the vascular bed examined

(2023) 15:e46741