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Left ventricular dysfunction should be managed with agents that provide afterload reduction (eg, angiotensin converting enzyme inhibitors) and have been shown to enhance survival in non-ESRD patients

Pregnant or breastfeeding women, people with thyroid disorders, and those with seizure history should exercise particular caution before starting supplementation

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Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects

Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca 2+ Structure 1998

If carnitine supplementation is coupled with supplemental intake of lysine (and to a lesser degree, methionine), a smaller dose of carnitine can be taken, which should forestall any side effects