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The copper component can cause localized burning, redness, or irritation in some individuals

However, each criterion does have a winner that stood out from the rest for one reason or another

Phase 2 Human Trials: Modest but Real Fat Loss Metabolic Pharmaceuticals conducted a Phase 2b randomized, double-blind, placebo-controlled trial in approximately 300 obese adults

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[DOI] [PubMed] [Google Scholar] 71.de Heer J, Rasmussen C, Coy DH, et al

Arterial vascularization of the pineal gland is supplied by both the anterior and posterior circulation, being the main artery supplying the lateral pineal artery, which originates from the posterior circulation (4)