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Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates

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These regulatory RNAs serve as metabolic rheostats, critically governing glucose homeostasis, lipid turnover, and brown adipose tissue thermogenesis through epigenetic modulation ( in vivo and in vitro experiments further have demonstrated that resveratrol promotes fatty acid catabolism and suppresses lipid droplet formation and accumulation via enhancing the activity of AdipoQ-AdipoR1-AMPK- and AdipoQ-AdipoR2-PPAR- signaling pathways