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Currently, no FDA-approved assays are available for quantifying key RCD pathway activation markers (such as GSDMD-N fragment for pyroptosis, phosphorylated MLKL for necroptosis) in clinical practice, making accurate patient stratification difficult (178, 179)

Subcellular Targeting A major advantage of genetically encoded sensors is the ability to target them to specific organelles

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Sies H, Belousov VV, Chandel NS et al (2022) Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

This approach is commonly used to separate fragment behavior from broader endocrine effects in mechanistic studies

Curcumin inhibited proliferation and induced apoptosis in chronic myeloid leukemia cell lines, particularly K562