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Pharmacokinetics parameters were not reported in the study results and data has not yet been published in scientific journals

To fully realize the potential of simple CD-based rotaxanes, future research efforts should be devoted to developing efficient template-directed synthesis methods 107,108,109,110

P., Shymkiv, Y., Mukai, J., Gogos, J

The demonstrated importance of protecting the terminals to pharmacokinetic characteristics suggests numerous additional synthetic approaches that may be applicable including the insertion of non-peptide linkages between the first and second amino acids, the replacement of the N~terminal amino acid with a non-a amino acid, and N-terminal acylation

Besides cell death, ROS generated from oxidative stress also triggers SIPS

In mitochondria, pyruvate is decarboxylated by pyruvate dehydrogenase kinase 1 (PDK1) to generate acetyl coenzyme A (76)