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Chaudhary, N., Weissman, D

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Although we did not find any significant difference between soluble Flt-1, also known as vascular endothelial growth factor receptor 1, levels in the plasma of R and LC patients, LC group exhibits a significant plasma elevation compared to the HC cohort ( Figure 6I )

Although the role of adipocyte-derived MTs is not fully understood, it is speculated that these stress-response and metal-binding proteins may act as antioxidants, shielding fatty acids from oxidative harm in adipocytes and during their transit from the micro-vasculature [18]

We, therefore, aimed to systematically review the molecular and pathophysiological mechanisms of hyperprolactinemia and obesity, focusing on key central and peripheral pathways, supported by current experimental and clinical evidence ( Figure 1 )

Funding Statement Deans Award, Pritzker School of Medicine, The University of Chicago