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In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26

Expected timeline: Similar pattern to topical-only but potentially accelerated and more pronounced results due to enhanced absorption

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View Abstract [15] de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA

Recombinant human growth hormone, insulin-like growth factor 1, and combination therapy in AIDS-associated wasting