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Acetyl-L-carnitine is neuroprotective when administered at supraphysiological concentration [114]

A 2020 update did caution, however: Based on the currently available evidences, the role of ALC [acetyl-L-carnitine] in AD and other cognitive disorders is still under debate

However , the supplemented group did show a significant difference in cellular ammonia levels , indicating that carnitine may help shuttle waste away from the cells, ultimately reducing the metabolic stress of exercise (or alcohol consumption!)

Voltage-gated L-type calcium channel inhibitor 1-(3-chlorophenethyl)-3-cyclopentylpyrimidine-2,4,6-(1H,3H,5H)-trione attenuated SCI-induced muscle spasms in mice by inhibiting Cav1.3 subunit specifically

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ALC is known for its role in hippocampal neurogenesis and in the modulation of neurotrophic factors like NGF, GDNF, and BDNF in specific brain regions [158, 162-165]