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The PINK1 and Parkin mediated pathway represents the most well characterized inducer of mitophagy

Lysates were pre-cleared with control beads (30 min, 4 C) and incubated with Molidustat (10 M) or DMSO (30 min, 4 C)

Compared to genomics, it can more directly reflect the dynamic changes in cellular life activities

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GlyNAC (glycine and N-acetylcysteine) supplementation improves impaired mitochondrial fuel oxidation and lowers insulin resistance in patients with type 2 diabetes: results of a pilot study