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Increased oxidative stress or deficient antioxidant status is critical in the pathogenesis of rheumatoid arthritis.[60,61] Some antioxidants including SOD and Vitamin E have an anti-inflammatory role in experimentally induced arthritis.[61] It was found that SOD activity is low in patients suffering from rheumatoid arthritis and the administration of SOD through liposomes had a positive effect in the treatment of experimental arthritis.[62,63] SOD and neurodegenerative diseases Oxidative stress has been shown to be involved in the pathophysiology of several neurodegenerative diseases