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Further, this results in ischemic insult due to ATP depletion at the site, raising energy demands, thus reducing the normal transportermediated uptake of glutamate [2]

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Biochemistry 85 , 288299 (2020)

Puche et al., 2013)

This phenomenon is thought to operate particularly in those neuronal systems using glutamate as a transmitter, such as the cells in the hippocampal areas mentioned previously

CPT1C is a brain-specific carnitine palmitoyltransferase 1 paralog that binds malonyl-CoA but lacks normal enzymatic activity 305,306