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Since B12 cannot be made by the body, it has to be procured from food or supplements

Lipo shots also aren't recommended for areas with very loose skin, as they address fat but don't tighten skin tissue

Novo Nordisk submitted an NDA (new drug application) to the FDA on December 18, 2025, which is the formal step companies take when seeking approval for a medication to be marketed for public use

Pairing it with niacinamide is sometimes raised as a concern