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ICH E14 and S7B, released in 2022, establishes a connection between clinical evaluation (ICH E14) and preclinical assessment (ICH S7B) in the context of cardiac safety during drug development

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Minder E.I., Barman-Aksozen J

107 In addition, 3 of 11 AML patients with IDH mutations achieved a complete response following the ABT-199 treatment

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Analytical size-exclusion chromatography ZSWIM8ELOB/C, ZSWIM8 mono ELOB/C and ZSWIM8 dimer ELOB/C (10 M) were each incubated with CUL3RBX1 (12 M) in 25 mM HEPES, 150 mM NaCl and 1 mM TCEP, pH 7.5, at 4 C for 30 min before analysis by size-exclusion chromatography (Superose 6, Cytiva)