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Laser Doppler Flowmetry Gingival blood flow (GBF) was measured by laser doppler flowmetry (LDF, Oxford Optronix Ltd, Oxford, UK) working at 780 nm

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Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs

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Because B12 is critical for neurological function, DNA production, and red blood cell development, a shortage can have wide-reaching effects