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Description
Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity
Wettschureck, N
1-30C, away from light
Fecal occult blood test: This will confirm whether the black color of the stool is due to blood loss or other causes
Severe stomach pain may feel sharp, deep, or continuous and does not settle with time, rest, or dietary changes
Understanding this mechanism matters because it explains why most GI side effects are dose-dependent, temporary, and manageable through titration strategies
