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While human clinical trials are still needed, the preclinical evidence is compelling

When overactive, it lowers NAD+ levels and promotes fat accumulation , particularly in visceral (deep belly) fat

Alpha 2 Macroglobulin (2M) inhibits all 4 classes of proteases, including the enzymes that breakdown joint cartilage

This may influence the overall conclusions drawn from this review and caution should be exercised in interpreting the results

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Severe side effects include an increased risk of diabetes and certain cancers