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Described complex provides a direct Ca2+ ions transfer from ER to mitochondria and is essential for Ca2+ homeostasis, while disturbances in this interaction promote ER stress, which has been demonstrated in DMD patients (50, 61)

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Overall, the DNA methylation status of brain neurons may be determined, not only by expression levels of DNA methylation/demethylation enzymes, but also by levels of SAMe

In addition, EOR can be inhibited by antioxidants and calcium channel antagonists, and can be activated by drugs that promote the release of calcium ions, indicating that EOR may be related to calcium storage and ROS production (Lin et al., 2009)

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While these findings are exciting, it's important to remember that the therapy has only been tested in animal models so far