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SAEs relatedness to the administration of vitamin B 12 or placebo will be judged by the investigator/designee, the Ethics Committee and the DSMB who will have access to all relevant investigations, clinical assessments and if require unblinding allocated interventions

22 Vitamin B12 : Low levels can contribute to fatigue and neurological symptoms

Blunted or impeded therapeutic response to vitamin B12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency

Age Ageing 2007;36:177-83

For autoinjectors, the force of the injector hitting the skin activates the needle

Mistake 5: Incorrect Math