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Description
Wada, S

J-PR, AN, and DL supervised the work
7 Changes in the brain cytoplasmic [NAD + ]/[NADH] and [NADPH]/[NADP + ] with aging are rodent strain and species specific Through measuring the metabolome of young and aged C57BL/6J mouse brains, the lactate/pyruvate, a proxy for the cytoplasmic [NADH]/[NAD + ], was found to increase by 34%52% with aging, indicating a cytoplasmic reductive shift (Dong and Brewer, 2019), opposite to the oxidation of mitochondrial [NADH] that was found to occur in aged neurons (Dong et al., 2019a)
PMID 22300046
ocular redness (OTC - Lumify ): eye drops to cause vasoconstriction of small venous capacitance vessels that predominantly express the alpha-2 receptor subtype (Corboz et al, 2008

doi: 10.2741/A432