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Recent studies have discovered numerous glutamine-activated mTORC1 pathways within tumor cells, which are responsible for promoting unlimited cell growth and proliferation [128, 145, 146]

Angiogenesis has been proved to favor tumoral promotion, migration, invasion, resistance to therapy and apoptosis, and relapses [333]

374,375,376 Bacteroides dorei BDX-01 downregulates the expression of NLRP3, ASC and Caspase-1 in colon tissues and reduces the secretion of IL-1 by regulating bile acid metabolism pathways

This allows for less frequent dosing compared to Sermorelin

Therefore, in the treatment of lung tumours with Keap1 deletion or Nrf2 overexpression, Nrf2 inhibitors should be administered to enhance the susceptibility of lung cancer cells to ferroptosis

doi: 10.1016/j.jhep.2013.01.035