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Both IV and oral administration results in a corresponding increase in cerebrospinal fluid (CSF) concentrations of ALC, indicating that it readily crosses the blood-brain barrier (BBB)

[DOI] [PMC free article] [PubMed] [Google Scholar] Ryschich E, Ntzel T, Hinz U, Autschbach F, Ferguson J, Simon I, Weitz J.r., Frhlich B, Klar E, chler MW, Schmidt J, 2005

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Initiation of therapy may be prompted by trough (pre-dialysis) plasma levocarnitine concentrations that are below normal (40-50 mol/L)

Kil, M.S., Kim, C.W

The data indicated that UHPSFC/MS shows promise in qualitative metabolomics analysis but requires further improvement, such as optimizing sample preparation to develop sensitive quantitative methods using UHPSFC/MS