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They are formed in the body from normal metabolism (such as converting food to energy) but are increased by exposure to environmental toxins, such as cigarette smoke and air pollution

258 While in the mitochondrial respiration-impaired cells, NAD + could reduce the exacerbated inflammatory response via improving lysosomal function

Contribution of infralimbic cortex in the cardiovascular response to acute stress

10.1111/j.1365-2796.2011.02488.x 85 JarrottB.HeadR.PringleK

To function correctly, neurons must produce adenosine triphosphate (ATP), exocytose synaptic vesicles, regulate intracellular calcium, and control neuronal membrane potential [9], and for these essential functions, they need mitochondria to supply energy in the form of ATP