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Patchy or "signet ring" calcification occurs in old cysts and degenerating adenomas, and has no such connotation

This process is initiated by specific receptor pathways in response to signals such as mitochondrial depolarization, ROS, and hypoxia

Mitochondrial dysfunction links ferroptotic lipid peroxidation to pyroptotic NLRP3 activation (Chen et al., 2023

OBrien Michigan Kidney Translational Resource Center (MKTC), funded by NIH/NIDDK grant U54DK137314, Michigan Diabetes Research Center, and the Michigan Diabetes Translational Research Center

11-0114-85), FITCIgE (clone R35-72

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