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Cell 157: 10881103 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM (2010) Cancerassociated IDH1 mutations produce 2hydroxyglutarate

The hydrophilic G-site specifically interacts with GSH

Maintenance phase: 25 mg once weekly for 48 weeks

Phagocytes produce large quantities of O 2 - through the enzyme NADPH oxidase for use in oxygen-dependent killing mechanisms, and this occurs in malarial infections

Think of it as a helper molecule that keeps your cells running

Alterations of the arginine metabolome in sickle cell disease: a growing rationale for arginine therapy